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All patients received supplementation with folic acid (500 μ g p.o., daily) and vitamin B 12 (1000 μ g i.m., every 9 weeks) commencing 1 week before the first cycle and continuing until the discontinuation of chemotherapy

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Size:250 ML

Intramuscular injections resulted in the vitamin B 12 concentration of over 1000 pg/mL already within a week, and after four weeks the value reached almost 3000 pg/mL [75]